As for the main options to use, there are two: framed and frameless glass railings. For the first type you will need additional materials:
Wood.
A wooden frame for glass railings will look really unique, as these materials are used less often in the common railing. Yet, you can use it to your advantage and create an innovative design for your patio with processed strong wood covered with paint or some form of protective finish and tempered glass.
However, wood is sensitive to moisture and temperature variations. Furthermore, it is easy to scratch or damage. So when choosing a glass railing system with wooden elements, remember it will require more care than metal-made constructions.
Metal.
The most commonly used frame and hardware (pillars, brackets, etc) material for making glass patio railing and top and bottom rails safe is metal. You can choose aluminum, steel, wrought iron of their alloys to create a beautiful design for your framed railing. The metal parts are used in all types of glass railing, as it supports the construction and connects the panels.
The prices for glass railing systems made of tempered glass and stainless steel are relatively high. However, they require low maintenance and can withstand temperature jumps and moisture. As a result, such glass rail systems appear cost effective in any part of the world.